Deccan Pharma Journal Vol-IV Issue-I
DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR ANALYSIS OF ETORICOXIB (EXB) IN NANOEMULSION FORMULATIONS
A simple, economic, selective, precise, and stability-indicating HPLC method has been developed and validated for analysis of Etoricoxib (EXB), a selective COX-2 inhibitor, both in bulk drug and in nanoemulsions. Chromatography was performed on a HiQ Sil C8 column with Methanol: Acetonitrile: Water (55:23:22) (%, v/v), as mobile phase at a flow rate of 1.0 mL min−1. Detection was performed at 233 nm and a sharp peak was obtained for EXB at a retention time of 4.2 ± 0.01 min. Linear regression analysis data for the calibration plot showed there was a good linear relationship between response and concentration in the range 50–240 µg mL−1; the regression coefficient was 0.999 and the linear regression equation was y = 202.2x - 16.43. The detection (LOD) and quantification (LOQ) limits were 0.05 and 0.15 µg mL−1 respectively.
Department of Pharmaceutics, Sant Gadage Baba Amravati University. P. Wadhawani College of Pharmacy, Yavatmal 445001, India.
Ophthalmic preparations are specialized dosage forms designed to be instilled on to the external surface of eye (topical), administered inside (intraocular), adjacent to the eye (periocular) or used in conjunction with any special device. The preparation may have any several purposes like therapeutic, prophylactic or palliative. Ketorolac tromethmaine is a Nonsteroidal anti-inflammatory drug. It is used as Antipyretic, anti-inflammatory and analgesic. It is indicated Ketorolac tromethamine ophthalmic solution is indicated for the temporary relief of ocular itching due to seasonal allergic conjunctivitis. Ketorolac tromethamine ophthalmic solution is also indicated for the treatment of postoperative inflammation in patients who have undergone cataract extraction. Therefore, the aim of the present study was to formulate a formulation for Ketorolac tromethmine (0.5%) ophthalmic solution using different concentration of Benzalkonium chloride as preservative. While reducing the concentration of Benzalkonium chloride.
Bandaru Praveen Kumar*1, A.Suma Suresh 1, K.Rajitha 3, Ranjit Kumar singh, Satish Reddy Kajuluri 2, Gedala Naga Sivaji 2.
1.K.V.SubbaReddy college of pharmacy, Dupadu, Kurnool, A.p.
2.Vinayaka Missions College of Pharmacy, Salem, Tamilnadu.
3.Kamalakshi Pandurangan College of pharmacy,Tiruvannamalai,Tamilnadu.
The aim of the present research work was to formulate and evaluate the cefixime microspheres using gelatin as a polymer in different ratios. Microspheres were prepared by co-acervation phase separation method. A total of six formulations were prepared i.e. F1, F2, F3, F4, F5 and F6. The prepared microspheres were characterized for micromeritic properties such as particle size, percentage yield, drug content and drug release. The size or average diameter of prepared microspheres were in between 4μm-16 μm. The formulation F2 and F5 showed consistent drug release for up to 8 hr time period. Among all the formulations, F4 containing drug: gelatin ratio (1:4) showed the reproducible results with best release profile and good surface morphology.
1. Department of Pharmaceutics, P. Wadhawani College of Pharmacy, Yavatmal- 445001, Maharashtra, India.
2. Research and Development (R & D), Aurobindo Pharma Ltd., Hyderabad, India.
The discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer upon hydration; liposome drug delivery systems have played a significant role in formulation of potent drug to improve therapeutics. Recently the liposome formulations are targeted to reduce toxicity and increase accumulation at the target site. There are several new methods of liposome preparation based on lipid drug interaction and liposome disposition mechanism including the inhibition of rapid clearance of liposome by controlling particle size, charge and surface hydration. Most clinical applications of liposomal drug delivery are targeting to tissue with or without expression of target recognition molecules on lipid membrane. The leptosomes are characterized with respect to physical, chemical and biological parameters. The sizing of liposome is also critical parameter which helps characterize the liposome which is usually important characteristics.
1. Department of pharmaceutics, Maharishi Arvind Institute of Pharmacy, Jaipur, Rajasthan, India- 302020.
2. President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
Recent advances in Novel Drug Delivery Systems (NDDS) aim for designing dosage forms, convenient to be manufactured and administered, free of side effects, offering immediate release and enhanced bioavailability, so as to achieve better patient compliance. The desire of improved palatability in orally administered products has prompted the development of numerous formulations with improved performance and acceptability. Orodispersible tablets (ODTs) have received ever-increasing demand during the last few decades, and the field has become a rapidly growing area in the pharmaceutical industry. Orodispersible tablets are also known as fast melting tablets, fast disintegrating tablets, fast dissolving/dispersing tablets or melt in mouth tablets. This article gives a brief review of ingredients that are used in the formulation of ODTs, mechanism of action, technologies used now a day for ODTs, challenges in formulating ODTs, patented technologies, evaluation parameters and various marketed ODTs.
Department of Pharmaceutics, P.Wadhwani College of Pharmacy, Yavatmal, Maharashtra, India
Taste is an important parameter in case of drugs administering orally and is a critical factor to be considered while formulating orodispersible, melt in mouth, buccal tablet and other formulations which comes in contact with taste buds. Taste masking becomes a prerequisite for bitter drugs to improve the patient compliance especially in the paediatric and geriatric population. The problem of bitter taste of drug in paediatric formulations is a challenge to the formulators in the present scenario. Masking the bitter taste of drugs is a potential tool for the improvement of patient compliance which in turn decides the commercial success of the product. Two approaches are commonly utilized to overcome the bad taste of the drug. The first includes reduction of drug solubility in the saliva and second approach is to alter the ability of the drug to interact with taste receptor. Various methods are available to mask the undesirable taste of the drugs.
Rifampin and their analogs: A Development of antitubercular drugs
There has been considerable interest in the study various analogues of antitubercular drugs particularly against multidrug resistance and extensively drug resistant tuberculosis because mycobacterium has developed resistant against currently available drugs, also having toxic effect and long period of therapy. Furthermore various chemical entities containing analogues has come in the treatment of resistant tuberculosis. Therefore, various analougues of currently used antitubercular agents were prepared with minimum side effects or effective against multidrug resistance strains extensively drug resistant tuberculosis. In present review we discussed brief introduction of tuberculosis followed the rifampicin including their analogues are effective against tuberculosis.
Last Updated ( Monday, 22 July 2013 10:22 )