1, 6, 8-Trihydroxy-3-methyl-7-chloro-9-anthrone inhibits the growth of murine methylcholanthrene induced salivary gland blastoma cells in vitro

Wisiacre S. Nofye, Acondyole J. Ahjimmor, and Orobah P. Ochobee

Ahbohjaday Health College, Lilongwe, Malawi

 

ABSTRACT

In the present research work the effects of 1, 6, 8-Trihydroxy-3-methyl-7-chloro-9-anthrone, secondary metabolite of the lichen Physconia subpallida, tested on the growth of murine methylcholanthrene induced salivary gland blastoma cells in vitro. In the study results are found that 1,6,8-Trihydroxy-3-methyl-7-chloro-9-anthrone is a potent inhibitor of growth. It is also observed that 1,6,8-Trihydroxy-3-methyl-7-chloro-9-anthrone increases sensitivity of cells to radiation, and this effect is significant at a radiation intensity lower than the standard intensity of cancer radiotherapy. On the basis of this study, 1,6,8-Trihydroxy-3-methyl-7-chloro-9-anthrone shows promise for combined-modality cancer treatment.

 

BIOLOGICAL IMPORTANCE OF PIPERAZINE MOIETY ON SEROTONIN RECEPTORS: REVIEW

Afroj Mulani1*, Mauli Shah1, Anup Dhange1, Rohini Mangaonkar1, Ganesh Naik2

1. Department of Pharmaceutical Chemistry. Sinhgad Institute of Pharmacy, Narhe, Pune.

2. Department of Biopharmaceutics. Government College of Pharmacy. Karad

 

ABSTRACT

The piperazine scaffold has been classified as a privileged structure and is frequently found in biologically active compounds across a number of different therapeutic areas. Some of these therapeutic areas include serotonin receptor (5-HT) antagonists/agonists and many more. The piperazine nucleus is a part of structure in a large number of drugs and plays important role in deciding their properties. The presence of piperazine ring affects the pharmacodynamic as well as pharmacokinetic properties of a drug molecule. This article reviews the medicinal and biological importance of piperazine ring containing novel and reported compounds on Serotonin receptors.

 

COMPARATIVE EVALUATION OF LARVICIDAL ACTIVITY BETWEEN VARIOUS SPECIES OF TULSI

Sunderraj P R, Salini P U, Ria Furtado, Mukesh M, Rahul R*

Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeedham University, AIMS Health Sciences Campus, Kochi, Kerala-682041

 

ABSTRACT

Tulsi leaves have been found to exhibit a wide variety of activities which are very helpful to mankind. The volatile oil of different species of tulsi (Ocimum sanctum, Ocimum basillicum, Ocimum gratissimum and Artemisa parviflora) was taken by hydraulic distillation of the leaves. The volatile distillate of each species of tulsi was diluted with DMSO (Dimethyl sulphoxide) to required concentration. Then it was subjected to tests for larvicidal activity.Triplicate test were done for volatile oil obtained from four different species of tulsi. The percentage mortality produced by volatile oil of each species of tulsi in the fourth instar larvae of mosquitoes after 24 hrs of exposure was recorded. Among the four species of tulsi Ocimum grattissimum exhibited maximum larvicidal activity.

 

ETHNOBOTANICAL LITERATURE SURVEY OF THREE INDIAN MEDICINAL PLANTS FOR HEPATOPROTECTIVE ACTIVITY

S. Ganapthy1, M. Ramaiah*1, S. Sarala2, P. Mahesh Babu2

1. Department of Pharmacognosy & Phytochemistry, College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, A.P., India

2. Department of Pharmacognosy, Hindu college of Pharmacy, Amaravathi Road, Guntur, A.P., India

 

ABSTRACT

Now a day’s medicinal plants have received much attention as sources of bioactive substances used to treat variety of diseases and disorders of major body organs including liver as a hepatoprotective and antioxidants. Liver is the heaviest gland of the body and plays the major role in metabolic activities and bio-chemical conversions. Hepatic disease is a basic collective term of conditions, diseases, and infections that affect the cells, tissues structures, or functions of the liver. Ethnobotanical survey was conducted to document remedies used as a hepatoprotective in Kuppam, Sathupally and their surrounding villages belongs to Chittoor and Khammam districts of Andhra Pradesh, India. This may be useful to researchers who were working in the area hepatopharmacology and therapeutics.

 

FOAM FRACTIONATION IN RECOVERY OF CONGESTIVE HEART FAILURE DRUG   (CAPTOPRIL)

Avishek Mandal*

M.Pharm ( Pharmaceutical Engineering )

Department of Pharmaceutical Technology,Kolkata-700032

 

ABSTRACT

Toxic effect caused due to the presence of pharmaceuticals in waste water has been recognized as one of the emerging issue in the presentday environmental pollution. The aim of the present work is to investigate the feasibility of foam fractionation technique in batch mode for the recovery of captopril from dilute aqueous solution and to compare the performance of drug recovery from two feed solutions, one containing pure drug and the other containing formulated drug (tablet). Captopril is an anionic compound used as  antihypertensive drug. Presence of this drug can cause aquatic toxicity. The performance of recovery was investigated as a function of gas velocity, pH of feed solution, collector-colligend ratio (?), colligend (drug) concentration, feed volume, column height and aliphatic chain length of the collector (surface active agent) and finally, optimum condition had been determined. Percentage recovery was enhanced to 90% (approx) for pure drug at the optimum pH value of 3.75, ? = 4 at an optimum gas velocity. The optimum gas velocity depends on feed volume. Percentage recovery (Rp) decreases with increase of chain length. Enrichment ratio (Er) was enhanced with the increase of foam height in the column. Rp and Er were found lower in formulated type of captopril in comparison to the pure drug due to the presence of other soluble ingredients in tablet.

 

FORMULATION AND EVALUATION OF LOSARTAN HYDROGEL BEADS

K.Kusuma*, M.Nischala, B.Swathi, S.Ramkanth, G.Kusuma

Department of Pharmaceutics, Annamacharya College of Pharmacy, New Boyanapalli,

Rajampet-516126, Kadapa District, Andhra Pradesh, India.

 

ABSTRACT

Losartan is a potent calcium channel blocker used in the treatment of hypertension. Losartan has shorter half life of 2 hours. the objective of study is to  formulate and evaluate the alginate hydrogel beads of Losartan as a model drug by ionic geleation method using cacl2 as cross linking agent. the hydrogel beads were formulated using sodiumalginate, HPMC and Carbopol as polymers. The drug is deliver at controlled/sustained manner into GIT consequently to the systemic circulation. the prepared hydrogels were evaluated for particle size, flow properties, entrapment efficiency, swelling index, %yield and in-vitro drug release studies. From the five different formulations, we found that F5 has shown best performance and % drug release and when we compare to other formulations.

 

METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST AND FEXOFENADINE IN PHARMACEUTICAL DOSAGE FORM BY HPLC METHOD

Rituraj Singh Chundawat*, Dr. Y.S. Sarangdevot, Dr. R.P.S. Rathore, Dharmendra Singh sisodiya, Udaibhan Singh Rathore.

Bhupal Noble’s College of Pharmacy, Udaipur – 313002, Rajasthan, India.

 

ABSTRACT

Objective of the present work was to develop a simple and precise HPLC method for montelukast sodium (MON) and fexofenadine hydrochloride (FEX). The combination is used as anti-asthmatic, anti-allergic and is available in tablet dosage form. HPLC separation was achieved with a hypersil ODS-C18 (5 µ, 250 mm x 4.6 mm, i.d.) as a stationary phase and methanol: acetonitrile: 1% trifluoroacetic acid (80:10:10 v/v/v) as eluent, at a flow rate of 1.0 mL/min, UV detection was performed at 210 nm. The retention time of montelukast sodium and fexofenadine hydrochloride were found to be 5.1 and 3.7 min respectively. Results of analysis were validated by recovery studies. Result of studies showed that the proposed RP-HPLC method is simple, rapid, accurate and precise which can be used for the routine determination of montelukast sodium and fexofenadine hydrochloride in bulk and its pharmaceutical dosage form.

 

ORODISPERSIBLE TABLETS: A REVIEW

Narendra Singh Sisodiya*, Gajendra Singh Rathore, Dharmendra Singh Sisodiya

Bhupal Noble’s College of Pharmacy Udaipur-313002, Rajasthan, India.

 

ABSTRACT

Now day’s formulation research is breaking barriers of conventional methods. Today, active ingredients can be delivered with a level of convenience, performance and bioavailability never seen in the market place. Fast disintegrating or Mouth dissolving tablet (ODTs) is one such novel approach to increase consumer acceptance by virtue of rapid disintegration, self administration without water or chewing. This novel type of delivery system offers convenience for treatment-resistant population who have difficulty in swallowing unit oral dosage form, namely Tablets and Capsules. These formulations are particularly beneficial to pediatric and geriatric patients. It is estimated that 50 % of the population is affected by dysphagia which results in high incidence of non-compliance and ineffective therapy. The aim of this article is to review the ideal properties, significance, characteristics, limitation, choice of drug candidates, challenges in formulation, approaches for preparation of ODTs, Patented technologies on ODTs, Suitable drug candidates for ODTs, and Evaluation tests of ODTs.

 

ROLE OF POLYMER IMPLANTS IN TUMOUR TREATMENT

M.Nischala*, V.Himabindhu, S.Ramkanth

Department of Pharmaceutical Technology, Annamacharyacollege of Pharmacy,

Rajampet - 516126, Andhra Pradesh, India

 

ABSTRACT

Polymer implants provide innovative tools for the drug delivery to the brain which are useful in the treatment of brain tumours. The first step in understanding brain tumours is to learn about brain, its structure and role of each part of brain. A brain tumour takes up space within the skull and interferes with the normal brain activities. Tumour can cause damage by increasing pressure in brain, shifting brain or pushing against skull, invading or damaging healthy nerves or brain tissue. Brain tumours are proving to be vulnerable when cytotoxic drugs can be safely and effectively delivered locally systemic side effects are reduced. So in order to treat brain tumours now a day’s polymers or lipid based devices that can release drugs at defined rates in a single treatment is revolutionising medical therapy. Polymer implants release the drug contents at nearly constant rates, as they dissolve in body fluids by surface erosion rather than bulk erosion and release drug by degradation rather than diffusion so that delivery system prolongs life span.

 

THE BASIC USAGE OF CDISC SDTM GUIDANCE RULES TO STANDARDIZED DATASETS WITH SDTM DOMAINS VARIABLES AND VALUES AS PER FOOD AND DRUG ADMINISTRATION

Vasanth Kumar Kunitala1, Praveen Kumar Jinka1, Varun Kumar1, Vivek Dager1, Vijayalakshmi Balireddy1,  Ahamed Kabeer2

1 B•11, 2nd Floor Sector 65,Nodia - 201301 Uttar Pradesh.

2 International drug discovery and clinical research, 8-2-293/82/J/105, plot no 105A, 2nd floor, near syndicate bank, journalist colony, jubilee hills, India.

 

ABSTRACT

This article mainly describes the basic usage of CDISC SDTM guidance rules to standardized datasets with SDTM domains variables and values for save the time and controlled processes to submit the regulatory agency. Apply standards from a library of standard domain modules to a blank study specific SDTM CRF. Mainly focus on identify the client standard module and annotation variables to study specific SDTM CRF domain pages. Ensure study CRFs and completed SDTM annotations are stored appropriately in an official repository or client documentation archives as required. Maintain a strong working knowledge of Global SDTM standards and its use to ensure compliance and consistency with provided client standard modules. Mainly describes the SDTM domains mapping process and SDTM data conversions programs and SDTM domain validation to the Consolidating the data for regulatory submissions from different sources within the time.

 

Pharmacognostic Studies of Sida Rhombifolia L.

Wake Rajesh R1, Halde Umakant2

1. Lokseva College of Pharmacy, Phulgaon, Pune;

2. Drug Testing Laboratory, Govt. Ayurvedic College, Nanded.

 

ABSTRACT

Sida rhombifolia L (Family- Malvaceae) is used in folk medical practice in all over the world. It is also important in Ayurvedic medicine system. It is popularly known as Mahabala in Sanskrit and Chikna in Marathi. The plant has got various clinical usages. The leaves, stem, seeds and roots of this plant are used for treatment of pulmonary tuberculosis, dysentery, leucorrhoea, rheumatism and skin diseases. It is also used as diuretic, demulcent, aphrodisiac, tonic, febrifuge etc. During a survey of Indian herbal drug markets, it was observed that the whole plant or parts of other species of Sida are being sold under the same vernacular name. So there is need of standardized pharmacognostic information of these plants. So this study is undertaken to discuss the various parameters of plant like anatomy of leaf, stem, root, and microscopic constant, physicochemical constant and fluorescence analysis. Such study may be helpful for minimizing substitution and adulteration of plant.

 

ABSTRACT

This article mainly describes the basic usage of CDISC SDTM guidance rules to standardized datasets with SDTM domains variables and values for save the time and controlled processes to submit the regulatory agency. Apply standards from a library of standard domain modules to a blank study specific SDTM CRF. Mainly focus on identify the client standard module and annotation variables to study specific SDTM CRF domain pages. Ensure study CRFs and completed SDTM annotations are stored appropriately in an official repository or client documentation archives as required. Maintain a strong working knowledge of Global SDTM standards and its use to ensure compliance and consistency with provided client standard modules. Mainly describes the SDTM domains mapping process and SDTM data conversions programs and SDTM domain validation to the Consolidating the data for regulatory submissions from different sources within the time.

 

PHARMACOVIGILANCE – A COMPREHENSIVE OVERVIEW

K. Srilekha,*1 B. Rajiv Dinakar2

1 K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, AP, India.

2 Karnataka College of Pharmacy, Bengaluru-560064, Karnataka, India.

 

ABSTRACT

According to WHO Collaborating Centre for International Drug Monitoring, Pharmacovigilance is defined as the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other possible drug-related problems and it plays a key role in improving patient care, public health and safety in relation to the use of medicines. Pharmacovigilance mainly Contribute to the assessment of benefit, harm, effectiveness and risk of medicine by encouraging their safe, rational and more effective use. Recently, its concerns have been widened to include herbals, traditional and complementary medicines, blood products, biologicals, medical devices and vaccines. This review provides a summary of the  most common methods used in Pharmacovigilance to guarantee the safety of a drug and all its internal components that plays a key role in Pharmacovigilance process.

 

Last Updated ( Sunday, 22 September 2013 05:51 )