Deccan Journal of Pharmaceutics and Cosmetology

 

Dendrimers: A Novel Therapy for Cancer

Sandip Vajir

Department of Pharmaceutics, Pataldhamal wadhwani college of Pharmacy,girija nagar yavatmal -445001M.S. India .

 

ABSTRACT

Dendrimer chemistry was first introduced in 1978 by Fritz Vogtle and coworkers. He synthesized the first “cascade molecules”, today known as dendritic molecules. The dendrimer architecture permits control over properties such as shape, size, density, polarity, reactivity and solubility. Dendrimer density functions and starburst limits can be easily modeled mathematically. Dendrimers have stimulated wide interest in the field of chemistry and biology, especially in applications like drug delivery, gene therapy and chemotherapy. A treatment of Cancer mainly focused on the targeting the active drug molecule at the site without affecting the neighbour cells and dendrimers have this property which is useful in diagnosis and treatment purpose which is a new hope in this area of Cancer treatment.[Full Text]

 

 

NIOSOMES AS A NOVEL DRUG DELIVERY CARRIER: REVIEW

Harish Rathi*, Rajesh Asija, Sangeeta Asija, Ashok Barupal, Umesh Kumar

Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India.

 

ABSTRACT

Niosomes are self-assembled vesicles composed primarily of synthetic surfactants and cholesterol. Niosomes are one of the best carriers for drug targeting. The method of preparation of niosomes is based on liposome technology. The basic process of preparation is the same i.e. hydration of the lipid phase by aqueous phase which may be either a pure surfactant or a mixture of surfactant with cholesterol. After preparing niosomal dispersion, unentrapped drug is separated by centrifugation, dialysis or gel filtration. Niosomes are promising vehicle for drug delivery and being non-ionic, it is less toxic and improves the therapeutic index of drug by restricting its action to target cells. Niosomal drug delivery is potentially applicable to many pharmacological agents for their action against various diseases. Niosomes have shown promise in the release studies and serve as a better option for drug delivery system. This review article deals with advantages, preparation, separation of unentrapped drug, factors affecting vesicles size, entrapment efficiency release characteristics of niosomes, evaluation of niosomes and applications of niosomes. [Full Text]

 

HYDROGEL-A NOVEL DRUG DELIVERY SYSTEM

Sandip Vajir

Department of Pharmaceutics, Pataldhamal Wadhwani College of Pharmacy,Girijanagar Yavatmal – 445 001, M.S. India .

 

ABSTRACT

The research on hydrogels is more than four decades old but there has been a tremendous growth in the recent past because of their unique bulk and surface properties. They form the basis of many novel drug delivery systems. Hydrogels is a modified cross linked polymeric formulation that form 3D network of hydrophilic polymer prepared from material such as gelatin, polysaccharide polymers etc. These are cross linked macro molecular networks that are insoluble but are able to swell rapidly in water or biological fluids It is because of these unique properties that these classes of polymer based systems embrace numerous pharmaceutical and bio medical applications. [Full Text]

 

NANO SUSPENSIONS - A SOLUBILITY ENHANCER

Rajesh Chatakonda*, M.Sekar, S.Jeevanandham, Kh.Hussan Reza,

Santhiram College of Pharmacy, Nandyal , Andhrapradesh.

 

ABSTRACT

Poor solubility and low bioavailability are one of the critical problems associated with many of the BCS CLASS II drugs. Many techniques have been developed to enhance the solubility of the poor soluble drugs but techniques have some limitations and hence have limited utility in solubility enhancement. Nanotechnology can be used to resolve the problems associated with these conventional approaches for solubility and bioavailability enhancement. Nanotechnology is defined as the science and engineering carried out in the nanoscale that is 10-9 meters. Among the different techniques in nanotechnology, nano suspensions are a unique technique that not only it solves the problem of poor solubility and bioavailability but it helps in altering the pharmacokinetics of drug and thus improve drug safety and efficacy. [Full Text]

Deccan Journal of Natural Products

 

Antidermatophytic activity of Essential Oils

Richa Sharma*, Gajanand Sharma and Meenakshi Sharma

1. Department of Biotechnology and Allied Sciences, Jayoti Vidyapeeth University, Jaipur.

2. Department of Chemical Sciences, Suresh Gyan Vihar University, Jaipur.

3. Lab No-1, Department of Botany, University of Rajasthan, Jaipur.

 

 

ABSTRACT

The antifungal potential of mixture of essential oils (turmeric and ginger) against common causes of dermatophytic infections in human was investigated via in- vitro investigations. In order to determine suitable oil mixture shows excellent antifungal activity (82mm, MIC 0.02μl/ml against T. rubrum, 79mm, MIC 0.04μl/ml against M.gypseum, 62mm, MIC 0.03μl/ml against C. albicans, 65mm, MIC 0.02μl/ml against M. furfur). The antifungal activity of oils was screened against C. albicans, M. furfur, T. rubrum and M. gypseum by using disc diffusion and microdiluation method. The inhibition zone of mixture of oils (Turmeric and Ginger) is higher than the single oils and reference antibiotics viz.- Clotrimazole (36mm against T. rubrum , 41 mm against M.gypseum) and Gentamycin (18mm against C. albicans, 16.5mm against M. furfur). From our findings, the results provide a scientific validation for the use of these essential oils in the treatment of dermatophytic infection and could be used in future for development of anti- skin diseases agents. [Full Text]

 

 

EVALUATION OF WOUND HEALING POTENTIAL OF MOMORDICA DIOICA FRUIT IN RATS

K. Raj Kumar1, K. Gnananath1, A. Sanjeeva Kumar1, K. Srinivas Reddy1, G. Hanumantha Reddy2

Ch. Srinivas Reddy1*

1Department of Pharmacognosy & Phytochemistry, Vaagdevi College of Pharmacy, Hanamkonda- 516001, Andhra Pradesh, India.

2Assistant Professor, Chhattisgarh Dental College & Research Institute, P.O. 25, Sundra, Rajnandgaon, Chhattisgarh-491 441, India.

 

ABSTRACT

Momordica dioica Roxb is a seasonal perennial, dioecious climber found trough out India. Traditionally it is having claim for its wound healing activity in folklore but till date there was no scientific evidence is available regarding its wound healing action. So, in present study an attempt was made to evaluate wound healing potential of this medicinally important plant. Wound healing activity was studied in two models in rat viz. excision and incision. In excision wound model parameters like wound contraction and period of epithelization was studied while in incision wound model, tensile strength of the wound was measured. In both the models treatment of wound with ointment containing 5% (w/w) extracts showed good wound healing activity (p<0.01) in comparison with control. The results of present study suggest that extracts of Momordica dioica Roxb Possess potent wound healing activity justifying its use in folklore.

[Full Text]

 

 

IN VITRO ANTI-ARTHRITIC ACTIVITIES OF LEAF EXTRACTS FROM KIRGANELIA RETICULATA BAILL.

Gunja Ahuja, Rupam Bharti, Yumnam Sileima and Shruthi SD*

P.G. Department of Biotechnology, The Oxford College of Science,

Bangalore-560 102, Karnataka, India.

 

ABSTRACT

Kirganelia reticulata is a medicinal shrub which has been valued for centuries in ayurvedic medicine. In view of the various medical properties and growing interest in the development of ecofriendly, biodegradable and safer herbal preparations the plant was screened for in vitro anti-arthritic property. Various in vitro models such as inhibition of protein denaturation, effect of membrane stabilization and proteinase inhibitory actions were studied. Methanol and chloroform extracts of dried leaves at 100μg/ml and 250μg/ml were used for the present study. Methanol extract of K. reticulata leaf at 250μg produced significant activity whereas 100μg dose did not produce significant results, which was followed by chloroform extracts, when compared with the standard drug acetyl salicylic acid. Production of auto-antigens in certain rheumatic diseases may be due to in vivo denaturation of proteins. Since the membrane of RBC is structurally similar to the lysosomal membrane, the effect of any substance on stabilization of RBC membrane may be extrapolated to the stabilization of lysosomal membrane. [Full Text]

 

Deccan Journal of Pharmacology

 

Assessment of Antioxidant and Analgesic properties of synthesized indole derivatives

Cinchana NV1, Sujan Ganapathy PS2 and Shruthi SD3*

1.Department of P.G. Studies and Research in Zoology, Kuvempu University, Shankaraghatta - 577 451, Karnataka, India

2.Centre for Vrikshayurveda, A Division of center for Advanced Studies in Biosciences, Jain University, Bangalore-560 019, Karnataka, India

3.P.G. Department of Biotechnology, The Oxford College of Science, Bangalore-560 102, Karnataka, India

 

ABSTRACT

Scientific evaluation was carried out by using synthesized indole derivatives, to prove their pharmacological potentials such as antioxidant and analgesic activities. Indole derivatives have a heterocyclic aromatic ring structure with high resonance stability and several different substituents on the ring, which suspects activities in these compounds on theoretical founds. Compounds I2 and I3 showed appreciable activities compared to compound I1. Whereas compound I4 showed very significant results which are almost equal to that of the standards BHT and Aspirin for antioxidant and analgesic activities respectively. The change in the potencies of the compounds may be attributed towards the structural differences of the indole derivatives[Full Text]

Last Updated ( Friday, 26 July 2013 02:20 )