Deccan Journal of Pharmaceutics and Cosmetology

Antioxidant activity of Glycrrhiza Glabra

 

Sandhya K. Desai*, Chandan H. Pandey, Smruti S. Mulgaonkar

Prin. K. M. Kundnani College of Pharmacy, 23-Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai- 400 005. India.


ABSTRACT

In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra (family: Leguminosae) have been employed clinically for centuries for their antiin?ammatory, antiulcer, expectorant, antimicrobial and anxiolytic activities. Antioxidant studies were carried out for Aqueous Liquorice Extract and Glabridin Rich Extract of Glycyrrhiza glabra which possess wide range of pharmacological actions. The extract was evaluated for in-vitro antioxidant activity by DPPH free radical scavenging activity, Hydroxyl radical scavenging activity and Lipid peroxidation at various concentrations ranging from 10 to 100 µg/ml and 100 to 1000 ng/ml respectively. Based on our findings, the Aqueous Liquorice Extract and Glabridin Rich Extract of Glycyrrhiza glabra showed very potent free radical scavenging activity. Therefore, it was concluded that Aqueous Liquorice Extract and Glabridin Rich Extract of Glycyrrhiza glabra showed potent in-vitro antioxidant activity.[Full Text]


FORMULATION AND EVALUATION OF PROSOPIS CINERARIA DRUCE PHYTOSOMES


Asija Sangeeta1*, Gopal Garg2, Rajesh Asija3, Chirag Patel3

1. C.M.J University, Shillong- 793003, Meghalaya, India.

2. V.N.S. Institute of Pharmacy, Bhopal-462044, M.P., India

3. Maharishi Arvind Institute of Pharmacy, Jaipur-302020, Rajasthan, India

Shanmukh C. Shetty

ABSTRACT

A novel formulation of Prosopis cineraria extract in combination with the phospholipids was developed to overcome the limitation of absorption and bioavailability. The aim of this study was to prepare and characterize Prosopis cineraria phytosomes. Prosopis cineraria phytosomes was prepared to improve the lipophilic properties of Prosopis cineraria extract. Phytosomes were prepared by rotary evaporator method. The physicochemical properties of the phytosomes including infrared spectrophotometry, % yield, solubility and apparent partition coefficient were determined. In addition, drug content and in vitro dissolution was evaluated. The results of infrared spectra showed that there was some interaction between drug (Prosopis cineraria methanolic exract) and phospholipid (soya lecithin) in the complex (phytosomes), but no new characteristic absorption peaks were observed, indicating that no new covalent bonds were formed.[Full Text]


FORMULATION DEVELOPMENT AND COMPARATIVE STUDY OF VENLAFAXINE HCl MOUTH DISSOLVING TABLETS BY USING SUPER DISINTEGRANT AND DILUENTS

Adimoolam Senthil1, Chauhan Pratik Navinchandra2, Ahmad bin Mahmud1, Natesan Gopal3

1. Department of Dosage Form Design, MAHSA University College Level 3, Block A, Pusat Bandar Damansara, Kuala Lumpur- 50490, Malaysia.

2. Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore-575028, Karnataka, India

3. Department of Pharmaceutical Chemistry, MAHSA University College Level 3, Block A, Pusat Bandar Damansara, Kuala Lumpur- 50490, Malaysia.


ABSTRACT

Venlafaxine HCl an antidepressant drug to circumvent the first pass metabolism. The objective of the present study was to formulate and comparative study of Venlafaxine HCl mouth dissolving tablets by using different superdisintegrants (croscarmellose sodium, crospovidone and sodium starch glycolate) and diluents (dibasic calcium phosphate and spray dried lactose) with various concentrations by direct compression method which is simple and cost effective. Diluents are inactive substance used as carrier for the active ingredients. Eighteen formulations F1-F18 were conducted for the selection of optimum concentration of superdisintegrant and diluents. The drug-excipients interaction was investigated by FTIR. Venlafaxine HCl mouth dissolving tablets were evaluated for various pre and post compression parameters like angle of repose, bulk density, tapped density, compressibility index, hausner’s ratio, tablet hardness, friability, weight variation, wetting time, water absorption ratio, in vitro dispersion time, drug content and in vitro dissolution. The optimum formulation was chosen and their optimum results were found to be in close agreement with experimental finding.[Full Text]

 

Quality control parameters and HPTLC fingerprinting of the roots of Calotropis procera (Ait.) R.Br.


Abhilasha Mittala* and Mohammed Alib

aFaculty of  Pharmaceutical Sciences, Jyoti Vidyapeeth Women’s University, Vedant Gyan Valley, Ajmer Express Way, NH-8, Jaipur – 302019 (Rajasthan),  India

b Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi - 110062, India

ABSTRACT

Calotropis procera (Ait) R. Br. (Asclepiadaceae)roots are used to treat anasarca, asthma, ascites, respiratory diseases, skin diseases and intestinal worms. The roots contained phenolic and acidic compounds, lipids, terpenoids and steroids. The roots contained 6.70 % of the total ash, 1.81 % of acid insoluble ash and 4.00% of the water soluble ash. There was 7.60 % of  water content as indicated by loss of drying. Successive extraction of the roots yielded 1.471 g, 1.014 g, 0.974 g and 3,428 g of the roots (25 g) in petroleum ether, chloroform, methanol and aqueous  extracts, respectively. Individual extractions of the roots (25 g) with these solvents produced 1.509 g, 6.06 g, 5.143 g and 6.405 g, respectively.The fluorescence studies of the roots indicated that light yellow colour in the day light and UV 254 nm light was changed to light blue fluorescence at 366 nm. Treatment of the root powder with conc. hydrochloric acid produced dark green fluorescence at 366 nm.Among the nine elements, potassium was present in the maximum amount (880.50 ppm) followed by calcium (280.90 ppm), magnesium (260.62 ppm) and cadmium (180.08 ppm).The HPTLC scanning of the petroleum ether and chloroform and methanol extracts of the roots exhibited 5, 4 and 4 major bands, respectively.[Full Text]

Last Updated ( Friday, 26 July 2013 02:33 )